Raghuraman Kannan, Ph.D
301 Business Loop 70 West Room 106
University of Missouri
Columbia, MO 65212, USA
Phone:(573)-882-5676  Fax:(573)-884-5679
Email: Kannanr@health.missouri.edu
 
Research Interests:
Application of Nanoparticles in the field of medicine.
Design and development of novel bifunctional chelate agents and their transition metal complexes, and investigate their applications for both catalysis and biomedicine.
Chemical and biomedical aspects of non-linear optical materials.
Development of new generation of chemotherapeutic agents.
Organometallic chemistry of specific transition metals with new chiral bisphosphanes and functionalized phosphanes-synthetic and catalytic aspects.
Structure of Water and Water-Methanol Clusters
 
Education:
M.S. Indian Institute of Technology, 1993
Chemistry Ph.D. Indian Institute of Science, 1999
Radiology Post-Doctoral Fellow, University of Missouri, 2000-2002
 
Academic Appointments :
Assistant Professor of Radiology, University of Missouri 2006-Present
Co-Director, Nanoparticles Production Core Facility, University of Missouri 2005-Present
Research Assistant Professor of Radiology, University of Missouri 2004-2006
Senior Research Scientist, Radiopharmaceutical Sciences Institute, University of Missouri 2002-2003
 
Professional Affliations/Activities :

Editor-in-Chief The Open Nanomedicine Journal (2008-); Bentham Publishers http://www.bentham.org/open/tonmj/EBM.htm

 Associate Editor and Special Issues Editor Synthesis and Reactivity in Inorganic and Metal-Organic and Nano-Metal Chemistry, (Focused journal on nanoscience) (2005-)

Founding Editor Journal of Nanotechnology; www.azanano.com (2006-)

Associate Editor International Journal of Green Nanotechnology (2008-)

Editorial Board Member Journal of Biomedical Nanotechnology (2006-)

Editorial Board Member Open Access Journal of Inorganic Chemistry (2007-)

Editorial Board Member Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry (2003-2004)

Journal Reviewer Journal of the American Chemical Society (JACS); Small Langmuir; European Journal of Medicinal Chemistry;
Nanotechnology;Journal of Nanomaterials; Journal of Nanoscience and Nanotechnology; Journal of Biomedical Nanotechnology
 
 
Research:
Designed and developed novel imaging agents for detecting GRP receptor specific cancers. (GRP receptor cancers:  Breast, Prostate, Small Cell Lung).  Developed a library of imaging agents by chemically modifying the backbone and performed detailed pharmacokinetic analysis in small animal models.
IMAGING MODALITY: SPECT
IMAGING AGENT BACK BONE: ORGANOPHOSPHINE FRAMEWORK
 
Worked in collaboration with scientists at MSKCC, New York in chemical modification of F18-FDG to increase retention in certain cancers.
IMAGING MODALITY: PET
IMAGING AGENT: CHEMICALLY MODIFIED FDG
 
Designed and developed a molecular backbone to stabilize and chelate Rh-105 for radiotherapeutic applications. Performed detailed preclinical trials on tumor shrinkage in small animal models. (Funded by Department of Energy)
THERAPEUTIC MODALITY: RADIOTHERAPY (ί-THERAPY)
AGENT BACK BONE: ORGANOPHOSPHINE FRAMEWORK
 
Targeted Gold Nanoparticles for Breast Cancer Imaging ROLE: Raghuraman Kannan (PI) This project is aimed to develop a highly sensitive imaging agent to detect breast cancer at an early stage.
IMAGING MODALITY: CT, BREAST-CT
IMAGING AGENT: GOLD NANOPARTICLES – CHEMICALLY MODIFIED
This project will also utilize BREAST-CT, developed at UC-DAVIS and currently under clinical trials, to enhance the imaging agent’s sensitivity.
 
Hybrid Nanoparticles in Imaging and Therapy of Prostate Cancer ROLE: Raghuraman Kannan (Lead Investigator)This project is aimed to develop a highly sensitive imaging agent to detect prostate cancer at an early stage.
IMAGING MODALITY: CT
IMAGING AGENT: GOLD NANOPARTICLES – PEPTIDE FUNCTIONALIZED
 
Positron Emitting Y-86 Coated Fluorescent Gold Nanoparticles as PET/OPTICAL Imaging Probe for Detecting Cancer ROLE: Raghuraman Kannan (PI)
IMAGING MODALITY: PET/OPTICAL – DUAL MODAL
IMAGING AGENT: GOLD NANOPARTICLES – Y-86 COATED
 
Gold Nanoparticles Enhanced Photoacoustic Breast Imaging ROLE: Raghuraman Kannan (PI); Evan Boote (PI)
IMAGING MODALITY: PHOTOACOUSTIC
IMAGING AGENT: GOLD NANOPARTICLES – PEPTIDE COATED
 
Gadolinium Coated Fluorescent Nanoparticles as fMRI/Optical Dual Probe for Brain Imaging ROLE: Raghuraman Kannan (PI) AGENCY: Dana Foundation
IMAGING MODALITY: MRI/OPTICAL
IMAGING AGENT: FLUORESCENT NANOPARTICLES – GADOLINIUM COATED
 
Targeted Gold Nanoconjugates for Imaging Apoptosis – CARDIOVASCULAR IMAGING ROLE: Raghuraman Kannan (PI) AGENCY: American Heart Association
IMAGING MODALITY: CT
IMAGING AGENT: NANOPARTICLES – ANTIBODY COATED
 
Publications:
Soybeans as a Phytochemical Reservoir for the Production and Stabilization of Biocompatible Gold Nanoparticles, Shukla R.; Chanda, N.; Nune, S. K.; Katti, K. K.; Kulkarni, R. R.;  Welshons W.  V.; Kannan R.*; K.  V. Katti, Small, 2008 (In Press)
 
Phosphinimines as selective extractants for Tc-99 pertechnetate, Arrigo, L. M.; Galenas, M.; Kannan, R.; Katti, K. V.; Jurisson, S. S. Radiochim Acta, 96, 2008, 175-181.
 
Naturally Occuring Gum Arabic as a Phyto Construct for the Stabilization of Gold Nanoparticles: In Vivo Pharmacokinetics and X-ray Contrast Imaging Studies, Kattumuri, V.; Katti, K. K.; Bhaskaran, S.; Boote, E. J.; Casteel, S. J.; Fent, G.
M.; Robertson, J. D.; Chandrasekhar, M.; Kannan, R.*; Katti, K. V. Small, 2007, 2, 333.
 
Organometallic chemistry of diphosphazanes. Part 26. Ruthenium hydride complexes of chiral and achiral diphosphazane ligands and asymmetric transfer hydrogenation reactions. Venkatakrishnan, Thengarai S.; Mandal, Swadhin K.; Kannan, Raghuraman; Krishnamurthy, Setharampattu S.; Nethaji, Munirathinam. Journal of Organometallic Chemistry 2007, 692, 1875-1891.
 
Kannan R.; Rahing, V.; Cutler, C. S.; Pandrapragada, R. K.; Katti, K. K.; Kattumuri, V.; J. David Robertson, J. D.; Casteel, S. J.; Jurisson, S.; Smith, C. J. ;Boote, E. J.; Katti, K. V. “Nanocompatible Chemistry toward Fabrication of Target-Specific Gold Nanoparticles”, J. Am. Chem. Soc, 2006, 128, 11342-11343.
 
Kattumuri, V.; Chandrasekhar, M.; Guha, S.; Kannan, R.; Katti, K. V.; Ghosh,K.; Patel, R. J. “Agarose-stabilized gold nanoparticles for surface-enhanced Raman spectroscopic detection of DNA nucleosides”, Appl. Phys. Lett, 2006, 88,
153114
 
Katti, K. V. Kannan R.; Rahing, V.; Cutler, C.; Pandrapragada, R. K.; Katti, K. K.; Kattumuri, V.; Robertson, J. D.; Casteel, S. J.; Jurisson, S.; Boote, E. J. “Hybrid Nanoparticles In Molecular Imaging and Therapy”, Czech.J. of Phy.
2006, 56, 23-34.
 
Kannan, R., Cutler, C. S.; Rahing, V.; Smith, C.J.; Katti, K. V. “Bioconjugated Radioactive Gold Nanoparticles and their In Vivo Targeting Abilities in Small Animal Models,” J. Nucl. Med 2006, 47, 510.
 
Design, Synthesis and Chemistry of Sterically Non-Demanding Primary Bis-Phosphines, N. Pillarsetty, R. Kannan, C. Barnes, K. V. Katti, J. Am. Chem. Soc2005, 127, 331-336.
 
Unprecedented rhodium-mediated catalytic transfer hydrogenation of a phosphonate functionalized olefin in ecofriendly media, R. Kannan, N. Pillarsetty, K. R. Prabhu, K. K. Katti and K. V. Katti, Inorganica Chimica Acta, 2004, 357, 2933-2938.
 
Optical and Phytophysical Properties of Gold Nanoparticles, K. V. Katti, V. Kattumurri, M. Chandrasekhar, A. Srinath, R. Kannan, K. Kavita Katti, Molecular Imaging, 3, 278, (2004).
 
Radiopharmaceutical Motif for Unified Tripodal Phosphino Dithioether Ligand Topology: Tumor-Seeking Peptide Conjugation and Tc-99m Metallation Studies. R. Kannan, N. Pillarsetty, H. Gali, T. Hoffman, W. A. Volkert, S. Jurisson, K. V.
Katti, Molecular Imaging, 3, 221, 2004
 
Characterization of Supramolecular (H2O)18 Water Morphology and Water-Methanol (H2O)15(CH3OH)3 Clusters in a Novel Phosphorus Functionalized Trimeric Amino Acid Host, R. Kannan, Kavita K. Katti, Leonard J. Barbour,
Nagavarakishore Pillarsetty, Charles L. Barnes, and Kattesh V. Katti, J. Am. Chem. Soc. 2003, 125, 6955-6961.
 
Radiochemical Investigations of Gastrin-releasing Peptide Receptor-specific [99mTc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, Tumor-bearing, Rodent Models: Syntheses, Radiolabeling, and in Vitro/in Vivo Studies where Dpr = 2,3-Diaminopropionic acid and X = H2O or P(CH2OH)3.
 
Smith, C. Jeffrey; Sieckman, Gary L.; Owen, Nellie K.; Hayes, Donald L.; Mazuru, Dana G.; R. Kannan; Volkert, Wynn A.; Hoffman, Timothy J. Cancer Research 2003, 63, 4082-4088.
 
Syntheses, in vitro and in vivo characterization of a 99mTc(I)-tricarbonylbenzylamino-dihydroxymethayl phosphine (NP2) chelate, K. K. Kothari, R. Kannan, N. K. Pillarsetty, T. J. Hoffman, N. K. Owen, K. V. Katti, W. A. Volkert, Applied Radiation and Isotopes 2003, 58, 543-549.
 
Exceptional Kinetic Propensity of Hydroxymethyl Phosphanes Toward Rh(III) Stabilization in Water, R. Kannan, N. Pillarsetty, W. A. Volkert, C. Barnes, S. Jurisson and K. V. Katti, J. Am. Chem. Soc. 2002, 124, 7276-7277.
 
First Examples of Azaphosphanes as Efficient Electron Donors in the Chemical Architecture of Thermally Stable New Nonlinear Optical Materials, K. V. Katti, R. Kannan, N. Pillarsetty, S. R. Karra, R. J. Gulotty, M. A. Chartier, and C. A.
Langhoff, Chemistry of Materials 2002, 14, 2436-2438
 
Novel Tridentate Water-Soluble Phosphane Based Ligands for Stabilizing Tc(I)/Re(I) Carbonyls for Radiopharmaceutical Applications, K.V. Katti, R. Kannan, N. Pillarsetty, W.A. Volkert, S.S. Jurisson and T.J. Hoffman Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. M. Nicolini, U.Mazzi Eds., SGE Editoriali, Padova, Italy. 2002, 6, 69.
 
Novel Green Chemistry in the Phosphonate Assisted Catalytic Hydrogenation of Olefins, R. Kannan, N. Pillarsetty, K. R. Prabhu, K. V. Katti, Phosphorus Sulfur and Silicon, 2002, 177, 1951.
 
Half-sandwich Cyclopentadienyl Ruthenium Complexes of Achiral and Chiral Diphosphazanes, R. Kannan, S. S. Krishnamurthy and M. Nethaji, J. Chem. Soc., Dalton. Trans., 2002, 22, 4289-4295.
 
New Phosphorus Chemistry Leads to Unnatural Aminoacid Trimers, K. V. Katti, R. Kannan, K. K. Katti, N. Pillarsetty, and C. L. Barnes, Phosphorus Sulfur and Silicon, 2002, 127, 1587-1589
 
Synthesis and Characterization of Ru(0), Rh(I), Pd(II) and Pt(II) ComplexesDerived from Diphosphazane Monosulfide Ligands: X-ray Crystal Structures of [Ru3(ì3-S)(ìsb-CO)(CO)7{ç2-(Ph2PN((S)-*CHMePh)PPh2)}] and [Rh(CO)Cl{ç2-(Ph- 2PN((S) *CHMePh)P(S)Ph2)}], R. Kannan, S. S. Krishnamurthy and M. Nethaji, J.Organometallic Chem., 2003, 669, 79-86.
 
Organometallic chemistry of Diphosphazane ligands: Synthesis and structural characterization: R. Kannan, Swadhin K Mandal, T S Venkatakrishnan, Setharampattu S Krishnamurthy and Munirathinam Nethaji". Proc. Ind. Acad of Sci. (Chem Sci.,) 2002, 114, 233-246.
 
Radiochemical Investigations of [99mTc(H2O)(CO)3-Dpr-(X)-Bombesin(7-14)NH2], a New Family of GRP-receptor Targeting Radiopharmaceuticals. Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.L.; Kannan, R.; Volkert, W.A.; and Hoffman, T.J. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. M. Nicolini, U. Mazzi Eds., SGE Editoriali, Padova, Italy. 2002, 6, 339.
 
Transition metal Chemistry of Diphosphazanes and Diphosphazane monosulfides, M. Ganesan, R. Kannan, S. S. Krishnamurthy and M. Nethaji, Phosphorus, Sulphur and Silicon, 1999, 147, 355.
 
A Novel Trinuclear n-Butyltin Cluster Incoporating Three Ferrocene CarboxylateSubstituents, K. C. Kumaraswamy, S. Nagabrahmanandachari and R. Kannan, J. Organomet. Chem., 1999, 587, 132
 
A. Ramesh; R. Kannan, M. S. Subramanian, T. V. Ramakrishna, Substoichiometric isotope dilution analysis for the determination of selenium by liquid scintillation counting. Analyst (Cambridge, U. K.) 1994, 119, 2067-70.
 
Full CV