Charles J. Smith
Assistant Professor
Office Address: Department of Radiology, University of Missouri, One Hospital Drive
Mailing Address: Radiopharmaceutical Sciences Institute, Room A005, 800 Hospital Drive , Harry S. Truman Memorial Veterans' Hospital, Columbia MO 65201
Phone: (573) 814-6000, ext. 3683
Fax: (573) 882-1663
Email: smithcj@health.missouri.edu

Education:

Ph.D. in Chemistry: May of 1997 University of Missouri-Columbia
Columbia, Missouri, 65211
Dissertation Advisors: Kattesh V. Katti and Richard Thompson
Dissertation Title: “Transition Metal Complexes of Novel, Polydentate, Water-Soluble, Phosphine Ligands”
B.S. in Chemistry: May of 1992 Missouri State University
Springfield, Missouri, 65897
Advisors: Robert Ernst and Tamara Jahnke
Undergraduate Research Thesis: “Selective Reactivities of Epoxyenones”

Professional Experience:

2003-present Assistant Professor, Department of Radiology, University of Missouri-Columbia School of Medicine and the Radiopharmaceutical Sciences Institute, Columbia, MO 6521
2005-present Research Scientist, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201
2003-present Research Assistant Professor, Missouri University Research Reactor, Columbia, MO 65211
2003-2005 Research Scientist WOC Appointment, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201
2003-present Research Assistant Professor, Department of Internal Medicine, University of Missouri-Columbia School of Medicine and the Radiopharmaceutical Sciences Institute, Columbia, MO 65211
2002-present Adjunct Assistant Professor, Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO 65211
2002-2006 Ambassador of the United States of America to the International Atomic Energy Agency

 

Recent Publications:
Peer-reviewed Professional Journal Articles:
  1. Faintuch, B.L.; Teodoro, R.; Duatti, A.; Morganti, L.; Muramoto, E.; Faintuch, S.; and Smith, C.J. “Radiolabeled Bombesin Analogs for Prostate Cancer Diagnosis: Preclinical Studies.” Nucl. Med. Biol., 2008, 35, 401-411.
  2. Lane, S.R.; Veerendra, B.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; Jurisson, S.S.; and Smith, C.J. “99mTc(CO)3-DTMA (DTMA = DIETHYLENETRIAMINE MONOACETATE) Bombesin Conjugates Having High Affinity for the GRP Receptor.” Nucl. Med. Biol., 2008, 35, 263-272.
  3. Prasanphanich, A.; Nanda, P.K.; Rold, T.L.; Ma, L.; Lewis, M.R.; Hoffman, T.J.; Sieckman, G.L.; Figueroa, S.D.; and Smith, C.J. “[64Cu-NOTA-8-Aoc-BBN(7-14)NH2] Conjugate: A Novel Targeting Vector for Positron Emission Tomographic Imaging of Gastrin Releasing Peptide Receptor-Expressing Tissues.” The Proceedings of the National Academy of Sciences USA, 2007, 104(30), 12462-12467.
  4. Kunstler, J-U.; Veerendra, B.; Figueroa, S.D.; Sieckman, G.L.; Rold, T.L.; Hoffman, T.J.; Smith, C.J.; and Pietzsch, H.J. “Organometallic 99mTc(III) 4+1 Bombesin(7-14)NH2 Conjugates: Synthesis, Radiolabeling, and In Vitro/In Vivo Studies.” Bioconjugate Chem., 2007, 18, 1651-1661.
  5. Ma, L.; Yu, P.; Veerendra, B.; Rold, T.L.; Retzloff, L.; Prasanphanich, A.; Sieckman, G.; Hoffman, T.J.; Volkert, W.A.; and Smith, C.J. “In Vitro and In Vivo Evaluation of Alexa Fluor 680-BBN[7-14]NH2 Peptide Conjugate; A High-affinity Fluorescent Probe Having High Selectivity for the GRP Receptor.” Molecular Imaging, 2007,6(3), 171-180.
  6. Alves, S.; Correia, J.D.G.; Rold, T.L.; Prasanphanich, A.; Haubner, R.; Rupprich, M.; von Guggenberg, E.; Alberto, R.; Decristoforo, C.; Santos, I.; and Smith, C.J. “99mTc(CO)3-Pyrazolyl Conjugates of RGD: In Vitro and In Vivo Evaluation of [99mTcL(CO)3-Cyclo[Arg-Gly-Asp-D-Tyr-Lys]] (L = A Tridentate Pyrazolyl-based Chelating Ligand Framework).” Bioconjugate Chem., 2007, 18, 530-537.
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  8. Prasanphanich, A.; Lane, S.R.; Figueroa, S.D.; Ma, L.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; McCrate, J.M.; and Smith, C.J. “The Effects of Linking Substituents on the In Vivo Behavior of Site-directed, Peptide-based, Diagnostic Radiopharmaceuticals.” In Vivo. International Journal of Experimental and Clinical Pathophysiology and Drug Research, 2007, 21(2), 3-18.
  9. Decristoforo, C.; Santos, I.; Pietzsch, H.J.; Duatti, A.; Smith, C.J.; Faintuch, B.L.; Rey, A.; Alberto, R.; von Guggenberg, E.; and Haubner, R. “Comparison of In Vitro and In Vivo Properties of 99mTc-RGD Peptides Labeled Using Different Novel Tc-cores.” The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2007, 51(1), 33-41.
  10. Kannan, R.; Rahing, V.; Cutler, C.; Pandrapragada, R.; Katti, K.V.; Kattumuri, V.; Robertson, J.D.; Casteel, S.J.; Jurisson, S.; Smith, C.; Boote, E.; and Katti, K.V. “Nanocompatible Chemistry Toward Fabrication of Target-Specific Gold Nanoparticles.” Journal of the American Chemical Society, 2006, 128(35), 11342-11343.
  11. Veerendra, B.; Sieckman, G.L.; Hoffman, T.J.; Rold, T.; Retzloff, L.; McCrate, J.; = Prasanphanich, A.; and Smith C.J. “Synthesis, Radiolabeling and In vitro GRP Receptor Targeting Studies of 99mTc-Triaza-X-BBN[7-14]NH2 (X = Serylserylserine, Glycylglycylglycine, Glycylserylglycine, or Beta Alanine).” Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-metal Compounds, 2006, 36(6), 481-491.

List of Presentations (Presenting Author Underlined)
Presentations at Nationally- and Internationally-held Conferences:

  1. Retzloff, L.B.; Smith, C.; Hoffman, T.; Rold, T.; Sieckman, G.; and Heinzke, L. “Breast Cancer Imaging.” The 7th Annual Meeting of the Society for Molecular Imaging, Nice, France, September 2008.
  2. Boote, E.; Smith, J.; Lever, J.; Watkinson, L.; Carmack, T.; Robertson, D.; Katti, K.; Kannan, R.; and Katti, K. “Gold Nanoparticles as a Computed Tomography Contrast Agent in SCID Mice with PC-3 Xenografts.” The 7th Annual Meeting of the Society for Molecular Imaging, Nice, France, September 2008.
  3. Lane, S.R.; Prasanphanich, A.F.; Nanda, P.K.; Rold, T.L.; Sieckman, G.L.; Hoffman, T.J.; Jurisson, S.S.; and Smith, C.J. “Development of Copper-64 Bombesin Conjugates for Use as Prostate Cancer Imaging Agents.” The 7th Annual Meeting of the Society for Molecular Imaging, Nice, France, September 2008.
  4. Volkert, W.A.; Hoffman, T.J.; Quinn, T.P.; and Smith, J. “Radiometallated SPECT Cancer Specific Imaging Radiopharmaceuticals.” American Nuclear Society: 2008 Annual Meeting, Anaheim, CA, June 8-12, 2008.
  5. Lane, S.R.; Jurisson, S.S.; Prasanphanich, A.F.; Nanda, P.K.; and Smith, C.J. “Copper-64 Bombesin Conjugates for Prostate Cancer Imaging.” Division of Nuclear Chemistry and Technology Graduate Student Symposium: The 236th National Meeting of the American Chemical Society, Philadelphia, PA, August 17-21, 2008.
  6. Kan, P.; Rahing, V.N.; Watkinson, L.D.; Carmack, T.L.: Lever, J.; Smith, C.J.; Loyalka, S.; Katti, K.V.; Cutler, C.S.; and Jurisson, S.S. “The Potential of Gum Arabic Stabilized Au-198 Nanoparticles (GA-AuNP) as a Radiotherapeutic Agent for Prostate Cancer.” 99th Annual Meeting of the American Association for Cancer Research, Los Angeles, CA, April, 2008.
  7. Ma, L.; Brown, A.; Kujala, N.; Smith, C.J.; Figueroa, S.D.; Yu, P.; Hoffman, T.J.; and Volkert, W.A. “Functional Apparent Diffusion Mapping the Uptake of Tumor-Targeting Bombesin Probes in Human Breast and Prostate Cancer Xenografts.” The 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, Toronto, Canada, May 2008.
  8. Ma, L.; Figueroa, S.D.; Brown, A.; Smith, C.J.; Garrison, J.; Yu, P.; Hoffman, T.J.; and Volkert, W.A. “Correlation Between In Vivo Uptake of Tumor-Targeting Bombesin Probes and Apparent Diffusion Coefficient Map in Human Cancer Xenografts.” The 6th Annual Meeting of the Society for Molecular Imaging, Providence, RI, August/September 2007.