FacultyInfo

Thomas P. Quinn
Associate Professor of Biochemistry
Office Address:	103 Schlundt Annex, University of Missouri-Columbia
Phone:	(573) 882-6099
Fax:	(573) 884-4812
Email:	QuinnT@missouri.edu
URL:	http://www.biochem.missouri.edu/tquinn.html

Education:
1988	Ph.D.	St. Louis University St. Louis, MO Molecular Virology
1983	B.S.	University of Miami Miami, FL Biochemistry
Professional Experience:
2000-present		Associate Professor of Radiology, University of Missouri, Columbia, MO.
2000-present		Director: Structural Biology Core, The Molecular Biology Program
2000-present		Research Scientist, Harry S. Truman Veterans Hospital, Columbia, MO
1998-present		Associate Professor of Biochemistry, University of Missouri, Columbia, MO.
1991-1998		Assistant Professor of Biochemistry, The Molecular Biology Program,University of Missouri, Columbia, MO
1988-1991		NIH Postdoctoral Fellow in the laboratory of Drs. David and Jane Richardson. Department of Biochemistry, Duke University , Durham NC . De novo design, synthesis and structural characterization of novel proteins.
8/88-10/88		Postdoctoral Research Associate in the laboratory of Dr. Dana Fowlkes. Department of Pathology, University of North Carolina, Chapel Hill NC.Generation of random CDR antibody libraries in phage.
9/83-8/88		Ph.D. Student in the laboratory of Dr. Duane Grandgenett. Institute for Molecular Virology, St. Louis University, St. Louis, MO.
Research Interests:
Biochemistry of Cancer, Combinatorial Biochemistry, Protein Structure/Molecular Dynamics Simulation, Radiopharmaceuticals, Structural Biology
Recent Publications:
Miao, Y., Whitener, D., Feng, Weiwei, Owen, N.K., Chen, J-Q., and Quinn, T.P. (2003) Evaluation of the human melanoma targeting properties of radiolabeled a -melanocyte stimulating hormone peptide analogues. Bioconjugate Chem. 14, 1177-1184. Glinsky, V.V., Glinsky, G.V., Glinsky, O.V., Huxley, V.H., Turk, J.R., Mossine, V.V., Deutscher, S.L., Pienta, K.J. and Quinn, T.P. (2003) Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Canc. Res. 63, 3805-3811. Khaldoyanidi, S.K., Glinsky, V,V., Sikora, I.L., Glinskii, A.B., Mossine, V.V., Quinn, T.P., Glinsky, G.V., Sriramarao, P. (2003) MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomasen-Friedenreich antigen-galectin-3 interactions. J. Biol. Chem. 278, 4127-4134. V.A. Petrenko, V.A., Smith, G.P., Mazooji, M. and Quinn, T. (2002) a -Helically constrained phage display library. Protein Eng. 15, 943-950. Miao, Y., Owen, N.K., Whitener, D., Gallazzi, F., Hoffman, T.J. and Quinn, T.P. (2002) Optimizing the tumor to kidney uptake ratios of 188 Re labeled a -MSH peptide analogs through chemical modification. In; Technetium, Rhenium and other metals in Chemistry and Nuclear Medicine-6 , Eds Nicolini and Mazzi, Servizi Grafici Eitoriali, Padova, Italy; pp 567-570. Miao, Y., Owen, N.K, and Quinn, T.P.( 2002). Therapeutic efficacy of 188 Re labeled (Arg 11 )CCMSH peptide in a murine melanoma bearing mouse model. In; Technetium, Rhenium and other metals in Chemistry and Nuclear Medicine-6 , Eds Nicolini and Mazzi, Servizi Grafici Eitoriali, Padova, Italy; pp 375-380. Miao, Y., Owen, N.K., Whitener, D., Gallazzi, F., Hoffman, T.J. and Quinn, T.P. (2002) In Vivo Evaluation of 188 Re Labeled Alpha-Melanocyte Stimulating Hormone Peptide Analogs for Melanoma Therapy. Int. J. Cancer 101, 480-487. Karasseva, N.G., Glinsky, V.V., Chen, N.X., Komatireddy, R. and Quinn, T.P. (2002) Identification and Characterization of Peptides that Bind Human ErbB-2 Selected from a Bacteriophage Display Library. J. Prot. Chem. 21, 287-296. Cheng, Z., Chen, J., Owen, N., Miao, Y., Quinn, T.P., and Jurisson, S.S. (2002) Modification of the structure of a metallopeptide: Synthesis and biological evaluation of 111 In labeled DOTA conjugated rhenium cyclized a-MSH analogs. J. Med. Chem. 45, 3048-3056. Chen, J. Q., Cheng, Z., Miao, Y., Jurisson, S.S., and Quinn, T.P. (2002) 99m Tc- and 111 In-labeled a -MSH Peptide Analogs for Malignant Melanoma Targeting. Cancer 94, 1196-1201. Chen, J-Q., Cheng, Z., Owen, N.K., Hoffman, T.J., Miao, Y., Jurisson, S.S., and Quinn, T.P. (2001) Evaluation of an 111 In-DOTA-Rhenium Cyclized a -MSH Analog: A Novel Cyclic-Peptide Analog with Improved Tumor Targeting Properties. J. Nucl. Med. 42, 1847-1855. Hoffman, T.J., Quinn, T.P., and Volkert, W.A. (2001) Radiometallated receptor-avid peptide conjugates for specific in vivo targeting of cancer cells. Nucl. Med. Biol. 28, 537-539. Glinsky, V.V., Glinsky, G.V., Rittenhouse-Olson, K., Huflejt , M.E. , Glinskii, O.V., Deutscher, S.L. and Quinn, T.P. (2001). The Role of Thomsen-Friedenreich Antigen in Adhesion of Human Breast and Prostate Cancer Cells to the Endothelium. Cancer Research 61 , 4851-4857.