Ma, Lixin

Lixin Ma
Assistant Professor of Radiology
Office Address:		B049 VA Research, 800 Hospital Drive , Harry S. Truman Memorial Veterans' Hospital, Columbia MO 65201
Phone:		(573) 814-6000 ext 53760
Fax:		(573)814-6559
Email:		MaL@health.missouri.edu

Education:
2000	Ph.D.	Chemistry, University of Copenhagen , Denmark .
1990	M.Sc.	Physics, Nankai University , Tianjin , China .
1987	B.Sc.	Physics, Nankai University , Tianjin , China .
Professional Experience:
2006 - present		Assistant Professor, Department of Radiology, International Institute of Nano and Molecular Medicine, Radiopharmaceutical Sciences Institute, University of Missouri-Columbia, Missouri.
2006 - present		Assistant Professor, Department of Radiology, International Institute of Nano and Molecular Medicine, Radiopharmaceutical Sciences Institute, University of Missouri-Columbia, Missouri.
2004 - present		Research Scientist (WOC), VA Biomolecular Imaging Center, Harry S. Truman Memorial Veterans Hospital, Columbia, MO
2004 - present		Adjunct Assistant Professor, Nuclear Science and Engineering Institute, University of Missouri-Columbia, Missouri.
2004 - 2006		Research Assistant Professor, Department of Internal Medicine, University of Missouri School of Medicine, Missouri.
2002 - 2003		Postdoctoral Associate, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, Indiana.
2000 – 2001		Postdoctoral Associate, Department of Chemistry, University of Copenhagen, Denmark.
1995 - 2000		Research Assistant, Department of Chemistry, University of Copenhagen, Denmark.
1990 - 1995		Assistant Engineer, Engineer and Lecturer, Clinical MRI Division, The 2nd Teaching Hospital, Tianjin Medical University, China.
Research Interests: Develop and apply non-invasive methods in biomedical imaging to research human cancer and cardiovascular disease. In particularly, to expose the unique functional and molecular properties of cancers, and to use these for improving early diagnoses and for evaluating and guiding cancer therapeutic research, by using MRI/MRS, PET, SPECT or Optical methodologies. My other interest is to study structure, dynamics and function of biological molecules using NMR spectroscopy. My other interest is to study structure, dynamics and function of biological molecules using NMR spectroscopy and molecular dynamics simulation.
Recent Publications:
H. Bigott-Hennkens, S. Junnotula, L. Ma, F. Gallazzi, MR. Lewis, and SS. Jurisson “Synthesis and In Vitro Evaluation of a Re-cyclized Somatostatin Derivative Series” J. Med. Chem., 2008, 51(5):1223-1230. L. Ma, P. Yu, B. Veerendra, TL. Rold, LR, AF. Prasanphanich, G. Sieckman, TJ. Hoffman, WA. Volkert, and CJ. Smith "In Vitro and In Vivo Evaluation of Alexa Fluor® 680-BBN[7-14]NH2 Peptide Conjugate: A High-affinity Fluorescent Probe Having High Selectivity for the GRP Receptor", Molecular Imaging, 2007, 6(3):171-80. AF. Prasanphanich, PK. Nanda, TL. Rold, L. Ma, MR. Lewis, JC. Garrison, TJ. Hoffman, GL. Sieckman, SD. Figueroa, and CJ. Smith “[64Cu-NOTA-8-Aoc-BBN(7-14)NH2] Conjugate: A Novel Targeting Vector for Positron Emission Tomographic Imaging of Gastrin Releasing Peptide Receptor-Expressing Tissues” Proc. Nat. Acad. Sci. of USA, 2007, 104(30): 12462-7. S. Balasubramanian, B. Carmignani, NG. Kujala, L. Ma, CJ. Smith, and P. Yu "Using Fluorescence Molecular Tomography for Multimodality Fusion Imaging", Proceedings of SPIE, 2007, Vol. 6431, 101-9. Prasanphanich, A.; Lane, SR.; Figueroa, SD.; Ma, L.; Rold, TL.; Sieckman, GL.; Hoffman, TJ.; McCrate, JM.; and Smith, CJ. “The Effects of Linking Substituents on the In Vivo Behavior of Site-directed, Peptide-based, Diagnostic Radiopharmaceuticals.” In Vivo-International Journal of Experimental and Clinical Pathophysiology and Drug Research, 2007, 21(2), 3-18. A. Whaley-Connell, G. Govindarajan, J. Habibi, MR Hayden, SA. Cooper, Y. Wei, L. Ma, M. Qazi, DL, PR Karuparthi, C. Stump, C. Ferrario, JR Sowers "Angiotensin-II mediated Oxidative Stress Promotes Myocardial Tissue Remodeling in the Transgenic TG (mRen2) 27 Ren2 Rat", Am J Physiol Endocrinol Metab. 2007 Apr 17; [Epub ahead of print]. G. Govindarajan, MR Hayden, SA. Cooper, L. Ma, SD Figueroa, TJ. Hoffman, C. Stump, JR. Sowers “Metabolic Derangements in the Insulin Resistant Heart”, J. CardioMetabolic Syndrome, 2006, 1;2:102-106. CV. Johnson, T. Shelton, CJ. Smith, L. Ma, MC. Perry, WA. Volkert, and TJ. Hoffman “Therapeutic benefit of combined GRP receptor targeted radiotherapy and chemotherapy in human prostate tumor cell xenografted SCID mice”, Cancer Biotherapy & Radiopharmaceuticals, 2006, 21(2), 155-165. L. Ma , CT. Johns, TD. Groesch, RJ. Kuhn, CB. Post “Solution Structure of Dengue Virus Capsid Protein Reveals Another Fold”, Proc. Nat. Acad. Sci. USA, 2004, 101, 3414-3419. CT. Johns, L. Ma, JW. Burgner, TD. Groesch, CB. Post, and RJ. Kuhn “Flavivirus Capsid is a Dimeric Alpha-Helical Protein”, The Journal of Virology, 2003, 77(12), p.7143-7149. L. Ma, MAS. Hass, N. Vierick, SM. Kristensen, J. Ulstrup, and JJ. Led “Backbone Dynamics of Reduced Plastocyanin from the Cyanobacterium Anabaena variabilis: Regions Involved in Electron Transfer Have Enhanced Mobility’, Biochemistry, 2003, 42(2), 320-330.