Beversdorf

The relationship between serotonin polymorphisms and prenatal stressors in children with autism as compared to Down syndrome and normal children.

Rodent model of the effect of prenatal stress on social behavior

Noradrenergic modulation of cognitive flexibility in autism.

fMRI demonstration of noradrenergic modulation of functional connectivity in autism.

fMRI demonstration of functional connectivity in cocaine withdrawal.

stress-related genes and cognitive effects of stress and PTSD

Mulitelectrode array research into human cognition and epilepsy

fMRI correlates of treatment response in mild cognitive impairment

Transfer of Care Communication Effectiveness for direct admits- prospective study.
PI- Hall L.W, MD, Department of Quality Improvement
University of Missouri, Columbia, MO

Retrospective study of pattern of use of Mannitol in management of stroke for past 5 years at University Hospital.
Co-Investigator : Sahota P, MD
University of Missouri, Columbia, MO

Ionized Magnesium at stroke onset in relation to cardiovascular risk factors and outcomes in stroke.
Co-Investigator: Sahota P, MD; Dabbagh O, MD
University of Missouri, Columbia, MO

Correlation between elevation of cardiac enzymes and BNP with anatomical locations of stroke over all stroke subtypes.
Co-Investigator: Sahota P, MD; Dabbagh O, MD University of Missouri, Columbia, MO

Brain Natriuretic Peptide and Serum Troponin I in relation to short term and long term outcomes of stroke.
Co-Investigator: Sahota P, MD; Dabbagh O, MD
University of Missouri, Columbia, MO

Beversdorf

"Development fund for autism neuroimaging research"
Principal Investigator: David Beversdorf, M.D.
Agency: Department of Radiology Type: University based internal award
(Beversdorf) Period 2/1/08-1/31/10
$400,000

"Effect of propranolol on eye contact in autism spectrum disorder"
Principal Investigator: David Beversdorf, M.D.
Agency: Thompson Center:
Type: University based foundation award (Beversdorf) Period 7/1/08-6/30/09
$24,508

Beversdorf

Campbell HL, Tivarus ME, Hillier A, Beversdorf DQ. Increased task difficulty results in greater benefit of noradrenergic modulation of cognitive flexibility. Pharmacology, Biochemistry & Behavior. 2008; 88: 222-229.

Tivarus ME, Hillier A, Schmalbrock P, Beversdorf DQ. Functional connectivity in an fMRI study of semantic and phonological processes and the effect of L-DOPA. Brain and Language. 2008;104:42-50.

Smith RM, Beversdorf DQ. Effects of semantic relatedness on recall of stimuli preceding emotional oddballs. Journal of the International Neuropsychological Society. 2008;14:620-628.

Pederzolli AS, Tivarus ME, Agrawal P, Kostyk SK, Thomas KM. Dopaminergic modulation of semantic priming in Parkinson disease. Cognitive and Behavioral Neurology. In press.

Beversdorf DQ, Carpenter AL, Miller RF, Cios JS, Hillier A. Effect of propranolol on verbal problem solving in autism spectrum disorder. Neurocase. In press.

Sahota P. Tired and Sleepy: Update on Sleep Disorders. Missouri Medicine 2006; 103(5): 501

Schuster SR, Tabba M, Sahota P. Relationship between the cardiometabolic syndrome and obstructive sleep Apnea. JCMS, 2006; 1: 204-208

Thakkar MM, Engemann SC, Walsh KM, Sahota P. Adenosine and the homeostatic control of Sleep: Effects of A1 receptor blockade in the perifornical lateral hypothalamus on sleep-wakefulness. Neuroscience 153 (2008) 875- 880

Sarwal A, Garewal M, Sahota S, Sivaraman M. Case report: Eight-and-a-half syndrome. Journal of Neuroimaging 2008; published online ahead of print

Thakkar M, Mallick BN (1991) Effect of REM sleep deprivation on rat brain acetylcholinesterase. Pharmacol Biochem Behav 39: 211-214.

Mallick BN, Thakkar M (1991) Short-term REM sleep deprivation increases acetyl-cholinesterase activity in the medulla of rats. Neurosci Lett 130: 221-224.

Mallick BN, Thakkar M (1992) Effect of REM sleep deprivation on molecular forms of acetylcholinesterase in rats. Neuroreport 3: 676-678.

Thakkar M, Mallick BN (1993) Rapid eye movement sleep-deprivation-induced changes in glucose metabolic enzymes in rat brain. Sleep 16: 691-694.

Thakkar M, Mallick BN (1993) Effect of rapid eye movement sleep deprivation on rat brain monoamine oxidases. Neuroscience 55: 677-683.

Mallick BN, Thakkar M, Gulyani S (1994) Rapid eye movement sleep deprivation induced alteration in neuronal excitability: Possible role of norepinephrine. In Environment and Physiology (Mallick BN and Singh R. eds), Narosa, New Delhi, pp. 196-203.

Mallick BN, Thakkar M, Gangabhagirathi R (1995) Rapid eye movement sleep deprivation decreases membrane fluidity in the rat brain. Neurosci Res 22: 117-122.

Thakkar M, Portas C, McCarley RW (1996) Chronic low-amplitude electrical stimulation of the laterodorsal tegmental nucleus of freely moving cats increases REM sleep. Brain Res 723: 223-227.

Portas CM, Thakkar M, Rainnie D, McCarley RW (1996) Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. J Neurosci 16: 2820-2828.

Thakkar M, Mallick BN (1996) Effect of rapid eye movement sleep deprivation on 5'-nucleotidase activity in the rat brain. Neurosci Lett 206: 177-180.

Thakkar, M, REM Sleep: A biochemical perspective. SRS Bulletin 1996; 2 22-28.

Portas CM, Thakkar M, Rainnie DG, Greene RW, McCarley RW (1997) Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat. Neuroscience 79: 225-235.

Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW (1997) Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 276: 1265-1268.

McCarley RW, Strecker RE, Porkka-Heiskanen T, Thakkar M, Bjorkum AA, Portas CA, Rainnie DG, Greene RW (1997) Modulation of cholinergic neurons by serotonin and adenosine in the control of REM and non-REM sleep (In Hayashi O and Inoue S Eds) Sleep and sleep disorders: From molecule to behavior, Harcourt Press, New York; pp. 39 - 56

Thakkar MM, Strecker RE, McCarley RW (1998) Behavioral state control through differential serotonergic inhibition in the mesopontine cholinergic nuclei: a simultaneous unit recording and microdialysis study. J Neurosci 18: 5490-5497.

Thakkar M, Ramesh V, Cape EG, Winston S, Strecker RE, McCarley RW (1999) REM Sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation. Sleep Research Online 2: 113-120.

Strecker RE, Thakkar MM, Porkka-Heiskanen T, Dauphin LJ, Bjorkum AA, McCarley RW (1999) Behavioral state - related changes of extracellular serotonin concentration in the pendunculopontine tegmental nucleus: A microdialysis study in freely moving animals. Sleep Research Online 2: 21-27

Basheer R, Porkka-Heiskanen T, Strecker R, Thakkar M, McCarley RW (2000) Adenosine as a biological signal mediating sleepiness following prolonged wakefulness. Biol. Signals Recept. 9:319-327.

Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, McCarley RW (2000) Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav Brain Res 115: 183-204.

Shiromani PJ, Lu J, Wagner D, Thakkar J, Greco MA, Basheer R, Thakkar M (2000) Compensatory sleep response to 12 h wakefulness in young and old rats. Am J Physiol Regul Integr Comp Physiol 278: R125-R133

Thakkar M, Ramesh V, Strecker RE, McCarley RW (2001) Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats. Arch. Ital. Biol 139:313-328

Thakkar M, Strecker RE, McCarley RW (2002) Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: Relevance to postulates of GABAergic inhibition of monoaminergic neurons. Brain Res. 945: 276-80.

Strecker, RE, Nalwalk, J, Dauphin, LJ, Thakkar, MM, Chen, Y, Ramesh, V, Hough, LB and McCarley, RW (2002) Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: An in vivo microdialysis study. Neuroscience 113: 663-670.

Thakkar M, Winston, S, McCarley, RW (2002) Orexin neurons of the lateral hypothalamus express adenosine A1 receptors, Brain Res. 944: 190-194.

Thakkar M, Winston, S, McCarley, RW (2003) A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain. J. Neurosci 23: 4278-87.

Thakkar M, Delgiacco, RA, Strecker RE and McCarley, RW (2003) Adenosinergic inhibition of basal forebrain wakefulness - active neurons: A simultaneous unit recording and microdialysis study in freely behaving cats. Neuroscience 122(4): 1107-13.

Bjorkum AA, Strecker RE, Portas CM, Porkka-Heiskanen T, Thakkar M, McCarley RW (2003) Perfusion of a 5-HT1A antagonist in the cat DRN increases wakefulness and extracellular 5-HT level in DRN. Sleep Research Online 5: 149-154

Ramesh, V, Thakkar M, Strecker RE, Basheer, R and McCarley, RW (2004) Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rat. Behav. Brain Res. 152: 271- 278.

Ma, Z, Strecker, RE, McKenna, JT, Thakkar, MM, McCarley, RW, Tao, R (2005) Effect of (-) nicotine and dimethylphenylpiprazinium on extracellular 5-HT in the dorsal raphe and nucleus accumbens of freely behaving rats. Neuroscience 135: 949-958.

Thakkar MM, McCarley RW (2005) Physiologic and Neurophysiologic Changes. In: Sleep Deprivation. Basic Science, Physiology and Behavior (Kushida CA, ed), Marcel Dekker, New York, pp. 265-291.

Tartar JL, Ward CP, McKenna JT, Thakkar MM, Arrigoni E, McCarley RW, Brown RE, and Strecker RE (2006). Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. E. J. Neurosci. 23: 2739-48.

Tao, R, Ma, Z, McKenna, JT, Thakkar, MM, Winston, S, Strecker, RE, McCarley, RW, (2006). Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats. Neuroscience 141:1101-1105.

Brown, RE, Winston, S, Basheer, R, Thakkar MM and McCarley RW (2006). Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins. Neuroscience 143:739-755

Chen, L, Thakkar, MM, Basheer, R, Winston, S, Yunren, B and McCarley, RW, (2006). REM sleep changes in rats induced by siRNA-mediated orexin knockdown E. J. Neurosci. 24(7):2039-48. Tao, R, Ma, Z, Thakkar, MM, McCarley, RW, and Auerbach, S (2007). Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a ?-opioid has no antagonistic effect on ?-opioid-induced increases in serotonin efflux. Neuroscience 147(1):106-16

McKenna, JT, Tartar, JL, Ward, CP, Thakkar, MM, Cordeira, JW, McCarley, RW and Strecker RE (2007) Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness Neuroscience 146(4):1462-73.

Brown, RE , McKenna, JT, Winston, S, Basheer, R, Yanagawa, Y, Thakkar MM, and McCarley RW (2008) Characterization of GABAergic neurons in rapid-eye-movement (REM) sleep controlling regions of the brainstem reticular formation in GAD67-GFP knock-in mice. E. J. Neurosci. . 27(2):352-63.

Thakkar MM, McCarley RW (2008) Histamine in control of sleep-wakefulness. In: Neurochemistry of sleep-wakefulness (Pandi-Perumal, Monti and Sinton ed), Cambridge University Press, Cambridge, pp. 144-178 Cambridge,

Thakkar, MM, Engemann, S, Walsh, K, Sahota P (2008) Adenosine and the homeostatic control of sleep: Effects of A1 receptor blockade in the perifornical lateral hypothalamus on sleep-wakefulness. Neuroscience. 153 (2008) 875- 880

Thakkar M, Winston, S, McCarley, RW (2008) Effect of microdialysis perfusion of THIP in the perifornical hypothalamus on sleep-wakefulness: Role of ?-subunit containing extrasynaptic GABAA receptors (2008). Neuroscience 153: 551-555.

Vij N, Sharma A, Thakkar, M, Sinha S, Mohan, RR. (2008) PDGF-driven proliferation, migration, and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway. Mol Vis. 14: 1020-7.

Thakkar MM, Datta, S. (2009). Evolution of REM sleep. (In press).

Thakkar MM, Sharma, R, Engemann, S and Sahota, P (2009) Adenosine and Glycine in REM sleep regulation (In press).

Beversorf

Kim N, Tivarus M, Goel P, Beversdorf D. The effect of L-DOPA on fMRI of language processing. Cognitive Neuroscience Society 15th Annual Meeting 2008.

Scaduto MJ, White CA, Saklayen SS, Narayanan A, Beversdorf D. The effect of propranolol on word fluency in autism spectrum disorder. American Academy of Neurology 59h Annual Meeting 2008.

Newman LK, Beversdorf D. Gender specificity of prenatal stress effects in autism. American Academy of Neurology 59h Annual Meeting 2008.

Smith RM, Edwards KS, Tilley MR, Gu HH, Givens BS, Beversdorf DQ. Serotonin transporter function and prenatal stress interact to modulate sociability in mice. International Meeting for Autism Research. 2008

Narayanan A, White C, Saklayen S, Abduljalil A, Schmalbrock P, Beversdorf DQ. Noradrenergic modulation of effective connectivity in autism spectrum disorder. International Meeting for Autism Research. 2008

Sarwal A, Dabbagh O, Sahota P. Relationship of Post Acute stroke Ischemic stroke ionized Calcium to Serum Troponin and Mortality. Annual meeting of American Academy of Neurology (AAN), Chicago, 2008

Mettu K, Sivaraman M, Sahota P. Restless Leg Syndrome & Periodic Limb Movement Disorder following multiple blood donations. Annual meeting of American Academy of Neurology (AAN), Chicago, 2008

Thakkar MM, Sahota P. Cellular mechanisms responsible for Somnogenic effects of Ethanol. Annual meeting of American Academy of Neurology (AAN), Chicago, 2008

Sunna R, Goodin J, Karpman C, Nistala P, Allcock D, Driver S, Sahota P, Johnson J, Dabbagh O. The relationship between chronic obstructive pulmonary disease and Obstructive Sleep Apnea. Associated Professional Sleep Societies Annual Meeting, Baltimore, Maryland, 2008

Mettu K, Lucchese S, Sahota P, Goyal M, Rajasekharan S, Sivaraman M. Co-morbidities associated with Obstructive Sleep Apnea in Non-obese patients. Associated Professional Sleep Societies Annual Meeting>, Baltimore, Maryland, 2008

Thakkar M, Engeman S, Sahota P, Mohan R. Adenosine in Ethanol induced Sleep. Associated Professional Sleep Societies Annual Meeting, Baltimore, Maryland, 2008

Sahota P, Mettu K, Soni S, Rajasekharan S, Sivaraman M. Clinical characteristics and prevalence of Obstructive Sleep Apnea in Non-obese patients. Associated Professional Sleep Societies Annual Meeting, Baltimore, Maryland, 2008

Mettu K, Garewal M, Goyal M, Sahota P, Rajasekharan S, Fuller L, Sivaraman M. Clinical Characteristic features of REM sleep related breathing disorder. Associated Professional Sleep Societies Annual Meeting, Baltimore, Maryland, 2008

Sarwal A, Norris S, Cummins M, Dabbagh O, Zanilleti I, Sarwal S, Sahota P. Validation of osmolar Gap to monitor Mannitol use in Ischemic stroke. Annual Meeting of Neurocritical care Society, 2008

Sarwal

Sarwal A, Garewal M, Sivaraman M. Case report -Fifteen and a half syndrome. 2007 Annual Meeting of American Society of Neuroimaging, Miami, FL. Winner of Resident Travel Award for outstanding abstract

Patel N, Thomas-Sohl K, Sarwal A et al. Reversible Cortical Atrophy and DWI Changes in Hypernatremia. 2007 Annual Meeting of American Society of Neuroimaging, Miami, FL.

Garewal M, Mettu K, Sarwal A et al. Prevalence and features of REM sleep-related breathing disorder. 2007 Annual Meeting of Associated Professional Sleep Societies, Minneapolis, MN

Mettu K, Garewal M, Sarwal A et al. Co-morbidities and cardiac arrhythmias in REM sleep-related breathing disorders. 2007 Annual Meeting of Associated Professional Sleep Societies, Minneapolis, MN

Mettu K, Garewal M, Sarwal A et al. Clinical characteristics and prevalence of supine-specific sleep-related breathing disorders. 2007 Annual Meeting of Associated Professional Sleep Societies, Minneapolis, MN

Sarwal A, Dabbagh O, Sahota P et al. Does Being On Statins and Antiplatelet Agents Prior To Stroke Affect Elevations of Troponin after Acute Ischemic Stroke? 2007 Annual Meeting of Neurocritical Care Society, Las Vegas, NV

Sarwal A, Dabbagh O, Sahota P et al. Serum Troponin and Brain Natriuretic Peptide (BNP) in Acute Ischemic Stroke. 2007 Annual Meeting of Neurocritical Care Society, Las Vegas, NV

Sarwal A, Dabbagh O, Sahota P et al. Serum Troponin and Brain Natriuretic Peptide (BNP) in Acute Ischemic Stroke. Health Sciences Research Day, 2007 School of Medicine, University of Missouri, Columbia, MO

Sarwal A, Burger R. et al. Use of Antiepileptic drugs- Gabapentin and Levetiracetam in Management of Acute Delirium. 2008 Annual Meeting of American Society of Experimental Neurotherapeutics, Arlington,VA.

Sarwal A, Dabbagh O, Sahota P et al. Relationship of Post Acute Ischemic Stroke Ionised Magnesium and Calcium to Serum Troponin and Mortality. 2008 Annual Meeting of American Academy of Neurology, Chicago, IL

Sarwal A, Dhand U et al. West Nile Encephalitis associated with Reversible Restricted Diffusion of Splenium of Corpus Callosum. 2008 Annual Meeting of American Academy of Neurology, Chicago, IL

Sahota S, Sarwal A. Acute Disseminated encephalomyelitis without clinical encephalitis. Internal Medicine 2008, American College of Physician Meeting, Washington, DC

Sarwal A, Norris S, Sahota P et al. Validation of Osmolar Gap to Monitor Mannitol Use in Ischemic Stroke. 2008 Annual Meeting of Neurocritical Care Society, Miami Beach Fl

Thakkar, MM, Sharma, R, Engemann, S., Walsh, K., Sahota (2009) Effect of ethanol on adenosine release and c-Fos activation in the basal forebrain. Soc. Of Neurosc. 552.23/Z9

Kelly, CE, Thakkar, MM, Will, MJ (2008) Intra-accumbens adenosine and its role in mediating palatable food intake: interactions with striatal opioids. Soc. Of Neurosc. 298.20/TT53.

Thakkar, MM, Engemann, S., Walsh, K., Sahota, P., Mohan, RR (2008) Cellular underpinnings of sleep induced by acute ethanol intake. Soc.Of Neurosc. 320.2

Thakkar, MM, Engemann, Sahota, P. Mohan, RR (2008). Role of Adenosine in Ethanol Induced Sleep. 22nd Annual Meeting of the Association of Professional Sleep Societies, Baltimore, June 7 - 12.

Thakkar, MM, Engemann, Akther, N, Sahota, P. (2008) Cellular mechanisms responsible for the somnogenic effects of ethanol. 2008 Annual meeting of the American Academy of Neurology, Chicago, April 12-19.

Thakkar, MM, Engemann, S., Walsh, K., Schlitt, J., Sahota, P. (2007) Microinjections of adenosine antagonist into the orexinergic lateral hypothalamus: Effects on sleep-wakefulness. Soc. Of Neurosc. 771.6.

Pritchett, CE, Thakkar, MM, Will, MJ (2007) Intra-accumbens adenosine-opioid interactions within a model of high-fat binge eating. Soc. Of Neurosc. 630.2/YY2

Brown RE, Winston S, Basheer R, Thakkar MM, Yanagawa Y, McCarley RW (2006) Electrophysiological recordings from brainstem GABAergic neurons in GAD67-GFP knock-in mice and REM sleep control by cholinergic and orexigenic mechanisms. Sleep 29 A45.

Brown RE, Thakkar MM, Winston S, Basheer R, Yanagawa Y, McCarley RW (2006) Characterization of brainstem GABAergic neurons controlling rapid-eye-movement (REM) sleep in GAD67-GFP knock-in mice. Federation of European Neuroscience Societies (FENS) meeting in Vienna, Austria.

Thakkar MM, Bolortuya Y, Winston S, Chen L, McCarley RW (2006) Microdialysis Perfusion Of Clonidine In The Orexinergic Perifornical Hypothalamus Reduces REM Sleep In Freely Behaving Rats Sleep A14.

Brown RE, Winston S, Basheer R, Thakkar MM, Yanagawa Y, McCarley RW (2005) Localization of green fluorescent protein (GFP) positive neurons in the brainstem of GAD67-GFP mice. Soc Neurosci Abs.

Thakkar MM, Tao R, Yunren B, Winston S, Chen L, McCarley RW (2005). GABA Release in the Orexinergic Perifornical Hypothalamus Is Highest during nonREM Sleep. Sleep 28: A12.

Thakkar MM, Tao R, Yunren B, Winston S, Chen L, McCarley RW (2004) GABA release in the pontine reticular formation is lowest during REM sleep. Soc Neurosci Abs 895.5.

Brown RE, Gritti I, Winston S, Thakkar MM, Basheer R, McCarley RW (2004) Characterization of EGFP-expressing putative GABAergic neurons in the subcoerulean reticular formation of the mouse. Soc Neurosci Abs 895.9.

Thakkar MM, Mello E, Winston S, McCarley RW (2003) GABAergic control of orexinergic neurons in the regulation of sleep-wakefulness. Sleep 26: A9.

Strecker RE, McCarley RW, Dauphin L, Wilkemeyer, M, Ramesh V, Thakkar MM (2001) Effect of diurnal variation and behavior state changes on extracellular levels of orexin-A in the rat brain. Sleep 24S: A25.

Cape, EC, Thakkar M, Ramesh V, Strecker RE, McCarley RW (2000) Basal forebrain unit recording in response to neurotensin perfusion in freely moving cats. Sleep 23 (S2): A123.

Strecker RE, Dauphin LJ, Wilkemeyer, M, Ramesh V, McCarley RW, Thakkar MM (2000) Extracellular levels of orexin-A in the hypothalamus of rat. Soc Neurosci Abst.

Thakkar MM, Strecker RE, McCarley RW (1998) Perfusion of 5-HT1A agonist in the dorsal raphe inhibits REM-Off neurons: A combined unit recording and microdialysis study. Sleep 21S: 3.

Thakkar M, Rainnie, DG, Hearn, EF, Green, RW, McCarley, RW, Shiromani, PJ (1997) Abnormal theta activity during REM sleep in ?-calcium-calmodulin kinase II knockout mice. Sleep Res. 26: 53

Thakkar M, Inglis WL, Rainnie DG, Green RW, McCarley RW, Semba K (1995) Effect on discrete ibotenic acid lesions of the mesopontine tegmentum on sleep and waking states in the rat. Soc Neurosci Abst. 2: 957